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A new 30-norfriedelane triterpnoid from Caloncoba lophocarpa (Oliv.) Gilg. (Achariaceae)
Antoine Salvial Tcheuko1, Bernard Samuel Fotso Hodjie2, Alain Tadjong Tcho3
1Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon.
Abstract:
The chemical investigation of the methanol extract of the roots of Caloncoba lophocarpa (Oliv.) Gilg. exhibited a new 30-norfriedelane triterpenoid, laphocarpanol (1), together with seven known compounds, caloncobalactone (2), friedelin (3), friedelanol (4), asperphernamate (5), stigmasterol (6), sitosterol (7) and sitosterol-3-O-β-D-glucopyranoside (8). The structures of the compounds were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. All the compounds were tested for their antifungal and antibacterial activities. Compound 1 displayed weak antibacterial effect with MIC value of 62.5 μg/mL against Shigella flexineri. All the isolates were found to be inactive against the tested fungal strains.
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