Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mismatch Repair01:36

Mismatch Repair

40.2K
Overview
40.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Current status and influencing factors of adolescents' awareness of functional gastrointestinal disorders and health education needs: a nationwide cross-sectional study.

Frontiers in pediatrics·2026
Same author

Boosting Few-Shot Continual Learning via Self-Adaptive Evolution.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society·2026
Same author

Functional implications of the conformational landscape of a multidrug transporter revealed by Zebrafish Abcb4 structures.

Nature communications·2026
Same author

Current Status and influencing factors of adolescents' awareness of functional gastrointestinal disorders and health education needs: a nationwide cross-sectional study.

Frontiers in pediatrics·2026
Same author

Optimization of automated radiosynthesis method for [<sup>18</sup>F]AlF-NOTA-Octreotide and PET/CT imaging in neuroendocrine neoplasms.

EJNMMI radiopharmacy and chemistry·2026
Same author

Efficient Transformation Product Identification and Structural Elucidation Using an Integrated Bottom-Up HRMS Workflow with Pyhrms and Transformapy.

Analytical chemistry·2026

Related Experiment Video

Updated: Jul 14, 2025

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

4.1K

Association between gut microbiota and benign prostatic hyperplasia: a two-sample mendelian randomization study.

Di Xia1, Jiahui Wang2, Xia Zhao1,2

  • 1Department of Reproductive Medicine, Zhongda Hospital Affiliated to Southeast University, Nanjing, China.

Frontiers in Cellular and Infection Microbiology
|October 6, 2023
PubMed
Summary

This study investigated the causal link between gut microbiota and benign prostatic hyperplasia (BPH). Certain gut bacteria, including Eisenbergiella and Ruminococcaceae, may reduce BPH risk, while Escherichia shigella may increase it.

Keywords:
benign prostate hyperplasiacausal inferencegenome wide association studygut microbiotamendelian randomization study

More Related Videos

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

28.2K
Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

19.2K

Related Experiment Videos

Last Updated: Jul 14, 2025

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

4.1K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

28.2K
Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

19.2K

Area of Science:

  • Microbiology
  • Genetics
  • Urology

Background:

  • Emerging research suggests a link between gut microbiota (GM) and various diseases.
  • The specific causal relationship between GM and benign prostatic hyperplasia (BPH) remains unclear.

Purpose of the Study:

  • To investigate the potential causal relationship between gut microbiota and benign prostatic hyperplasia (BPH) using a two-sample Mendelian randomization analysis.

Main Methods:

  • Utilized large-scale genome-wide association study data for GM (MiBioGen consortium) and BPH (FinnGen consortium).
  • Employed multiple Mendelian randomization techniques (IVW, MR-Egger, weighted median, etc.) to assess causality.
  • Assessed heterogeneity and horizontal pleiotropy using Cochran's Q, MR-PRESSO, and MR-Egger tests.

Main Results:

  • Eisenbergiella and Ruminococcaceae (UCG009) were associated with a reduced risk of BPH.
  • Escherichia shigella was associated with an increased risk of BPH.
  • Reverse Mendelian randomization confirmed no significant influence of BPH on these gut microbiota, with no detected heterogeneity or pleiotropy.

Conclusions:

  • A causal relationship exists between specific gut bacteria (Eisenbergiella, Ruminococcaceae UCG009, Escherichia shigella) and BPH.
  • These findings highlight potential microbial targets for BPH management.
  • Further research, including randomized controlled trials, is warranted to elucidate the mechanisms involved.