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Calcifying Nested Stromal-Epithelial Tumor: An Extremely Rare Hepatic Tumor
Bilal Ahmed Khan1, Imran Ali Syed1, Ihsan Ulhaq1
1Pakistan Kidney and Liver Institute & Research Center, DHA Phase VI, Lahore, Pakistan.
A rare liver cancer, calcifying nested stromal-epithelial tumor, was diagnosed in a young woman via biopsy. Surgical resection was successful, offering insights into this uncommon hepatic malignancy.
Area of Science:
- Hepatology
- Oncology
- Pathology
Background:
- Calcifying nested stromal-epithelial tumor (CNSET) is a rare hepatic malignancy.
- Fewer than 50 cases are documented in medical literature.
- Diagnosis relies heavily on histological examination.
Observation:
- A 24-year-old woman presented with nonspecific symptoms including abdominal pain and distension.
- Imaging revealed a large right hepatic lobe mass with portal vein invasion.
- Initial diagnostic modalities could not definitively characterize the lesion.
Findings:
- Ultrasound-guided biopsy confirmed the diagnosis of calcifying nested stromal-epithelial tumor.
- Histology showed nests of spindle and epithelioid cells with a desmoplastic myofibroblastic stroma.
- Variable calcification and ossification were noted within the tumor stroma.
Implications:
- This case highlights the diagnostic challenges posed by rare liver tumors.
- Accurate diagnosis of CNSET is crucial for appropriate management.
- Successful surgical resection offers a potential treatment pathway for this malignancy.
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