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Computed Tomography01:10

Computed Tomography

4.6K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.6K
Relative Motion Analysis using Rotating Axes01:25

Relative Motion Analysis using Rotating Axes

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Consider a component AB undergoing a linear motion. Along with a linear motion, point B also rotates around point A. To comprehend this complex movement, position vectors for both points A and B are established using a stationary reference frame.
However, to express the relative position of point B relative to point A, an additional frame of reference, denoted as x'y', is necessary. This additional frame not only translates but also rotates relative to the fixed frame, making it...
473
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Related Experiment Video

Updated: Jul 14, 2025

Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
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Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography

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High dynamic range 3D motion tracking using circular scans with optical coherence tomography.

Senyue Hao1, Marcello Magri Amaral2,3, Chao Zhou1,2

  • 1Department of Electrical & Systems Engineering, Washington University in Saint Louis, USA.

Biomedical Optics Express
|October 6, 2023
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Summary

This study introduces a novel circular optical coherence tomography (OCT) method to precisely track biological sample motion. This technique enables accurate motion compensation for enhanced microscopic and macroscopic imaging of live subjects.

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Area of Science:

  • Biomedical Imaging
  • Optical Physics
  • Microscopy

Background:

  • Motion artifacts from physiological processes (heartbeats, respiration, peristalsis) significantly degrade live subject imaging.
  • Accurate tracking of biological sample motion is crucial for high-resolution microscopy and macroscopic imaging applications.

Purpose of the Study:

  • To develop and validate a method for precise tracking of transverse and axial motion in biological samples.
  • To enable active motion compensation for improved in vivo imaging quality.

Main Methods:

  • Utilized circular optical coherence tomography (OCT) scans to capture sample movement.
  • Implemented adaptive control of circular scan pattern settings for optimized measurements.
  • Applied interframe and intraframe analyses for fast, high-precision motion quantification.

Main Results:

  • Successfully tracked biological sample motion across a wide speed range (micrometers/sec to centimeters/sec).
  • Achieved fast and high-precision measurements of motion magnitude and direction.
  • Demonstrated the potential for real-time motion compensation.

Conclusions:

  • The developed circular OCT method provides accurate motion tracking for biological samples.
  • This technique forms the foundation for advanced active motion compensation strategies.
  • Future in vivo microscopic and macroscopic imaging will benefit from this motion correction approach.