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Related Experiment Video

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A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
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Causal association between common rheumatic diseases and glaucoma: a Mendelian randomization study.

Yang Meng1, Zongbiao Tan2, Yu Su1

  • 1Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, China.

Frontiers in Immunology
|October 6, 2023
PubMed
Summary

Ankylosing spondylitis (AS) increases the risk of primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). Glaucoma screening is crucial for AS patients.

Keywords:
Mendelian randomizationSpondyloarthritisgeneticsglaucomarheumatic diseasessingle-nucleotide polymorphisms

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Genetic Epidemiology

Background:

  • Rheumatic diseases, characterized by autoimmunity and inflammation, are linked to glaucoma.
  • The causal relationship between rheumatic diseases and glaucoma risk remains uncertain.

Purpose of the Study:

  • To investigate the causal effect of six common rheumatic diseases on glaucoma risk.
  • Utilizing Mendelian randomization (MR) to assess genetic predispositions.

Main Methods:

  • Mendelian randomization (MR) analysis incorporating two-sample and multivariable MR approaches.
  • Genetic variants for ankylosing spondylitis (AS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), dermatomyositis (DM), gout, primary open-angle glaucoma (POAG), and primary angle-closure glaucoma (PACG) were analyzed.
  • Inverse-variance weighted MR served as the primary analytical method, supplemented by sensitivity analyses.

Main Results:

  • Ankylosing spondylitis (AS) demonstrated a significant association with increased risk for both primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG).
  • Multivariable MR confirmed the positive association between AS and higher risks of POAG and PACG.
  • No significant causal links were found between the other five rheumatic diseases and glaucoma.

Conclusions:

  • Ankylosing spondylitis (AS) is causally associated with an elevated risk of developing primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG).
  • Routine glaucoma screening is recommended for patients diagnosed with ankylosing spondylitis (AS).