Related Experiment Video
Updated: Jul 14, 2025
05:19
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
Published on: July 7, 2023
2.3K
Individualized Treatment Patterns for Patients with Narcolepsy Treated with Oxybate: A Clinical Practice Perspective
Asim Roy1, Diane Ito2, Susan Morris3
1Ohio Sleep Medicine Institute, Dublin, OH, USA.
Nature and Science of Sleep
|October 6, 2023
Summary
Physicians adjust oxybate dosing for narcolepsy patients to accommodate lifestyle changes like travel or alcohol consumption. Individualized dosing is key for effective narcolepsy treatment and patient care.
Area of Science:
- Neurology
- Pharmacology
- Sleep Medicine
Background:
- Real-world data on divided nightly dosing of oxybate for narcolepsy is limited.
- Individualized prescribing practices for oxybate require further investigation.
Purpose of the Study:
- To examine oxybate prescribing patterns in narcolepsy.
- To understand dose regimen optimization and adjustments for routine changes.
- To gather physician recommendations for patient scenarios.
Main Methods:
- A cross-sectional survey of 25 physicians treating narcolepsy patients with oxybate.
- Web- and audio-based survey on dosing regimens, discussions, and adjustment preferences.
- Physicians provided guidance for 4 representative patient scenarios.
Main Results:
- Prescribing practices varied, with different nightly dosing frequencies reported.
- Most physicians discussed dose adjustments for routine changes (e.g., travel, alcohol).
- Adjusting total dose and timing were preferred methods; physicians valued individualized dosing.
Conclusions:
- Physicians support oxybate dose adjustments for routine changes in narcolepsy patients.
- Individualized oxybate dosing is perceived as crucial for effective patient care.
Keywords:
calciumlow-sodium oxybatemagnesiumpersonalized dosingpotassiumprescribing patternssodium oxybatesodium oxybatesMore Related Videos
Related Concept Videos
01:24Sleep-Wake Cycles
1.4K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.4K
01:07Narcolepsy
122
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
122
01:19Management of Insomnia
266
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
266
01:24Substance Use Disorders Affecting Sleep
180
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
180
01:15REM Sleep Behavior Disorder
217
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
217
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
188
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
188