[Analysis of the Tumor Immune Microenvironment of Colorectal Cancer by Deep Learning-Based Imaging Cytometry]
Kimihiro Yamashita1, Toru Nagasaka, Yukari Adachi
1Dept. of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine.
Abstract:
The tumor immune microenvironment(TIME)of colorectal cancer contains indicators of unique therapeutic outcomes for each cancer patient. Deep learning-based imaging cytometry(DL-IC), which can obtain objective and reproducible cell- related information in tissue sections, has attracted attention as an analytical method for clarifying this indicator. This study demonstrates the validation process of Cu-Cyto, one of DL-IC, regarding cell identification accuracy. Acquisition of"spatial structure"information in TIME is useful for biomarker retrieval and contributes to precision oncology.
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