Related Experiment Video
Updated: Jul 14, 2025

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
[Two Cases of Catheter-Related Venous Thrombosis Treated with Direct Oral Anticoagulants(DOAC)]
Takayuki Terasawa1, Kaori Fukuda, Ai Yanai
1Dept. of Surgery, Sendai City Hospital.
Insights
Central venous access ports can cause venous thromboembolism. Direct oral anticoagulants effectively treated catheter-related thrombosis in breast cancer patients, showing a low risk of bleeding.
Area of Science:
- Oncology
- Vascular Surgery
- Hematology
Background:
- Central venous access ports are frequently used in breast cancer treatment.
- These ports are associated with an increased risk of venous thromboembolism (VTE).
- Catheter-related thrombosis (CRT) management guidelines recommend anticoagulation with the catheter in situ.
Abstract:
The implantation of a totally implantable central venous(CV)access port is considered a risk factor for venous thromboembolism( VTE). In the treatment of catheter-related thrombosis(CRT), both European and American guidelines recommend anticoagulation therapy with catheters in place. We experienced 2 cases of upper extremity deep vein thrombosis (UEDVT)after the implantation of CV access ports through the left subclavian vein for adjuvant chemotherapy in patients with resected breast cancer. Both patients were successfully treated with direct oral anticoagulants(DOAC) while the port remained in place with a careful follow-up that included monitoring of serum D-dimer levels. The administration of DOAC to CRT that develops in patients undergoing postoperative adjuvant chemotherapy for breast cancer may be relatively safe, with a low potential for adverse events such as bleeding.
Related Concept Videos
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Venous Thrombosis III: Interprofessional Care
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Venous Thrombosis IV: Nursing Management
Venous Thrombosis I: Introduction

