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Updated: Jul 14, 2025
06:38
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
13.6K
Perioperative systemic therapy in renal cell carcinoma
Ceilidh MacPhail1, Lori A Wood, Myuran Thana
1Division of Medical Oncology, Dalhousie University, Halifax, Nova Scotia, Canada.
Current Opinion in Supportive and Palliative Care
|October 6, 2023
Summary
Adjuvant pembrolizumab shows disease-free survival benefit for resected renal cell carcinoma (RCC). Patients with localized RCC should discuss this perioperative therapy option with their doctor to reduce recurrence risk.
Area of Science:
- Oncology
- Nephrology
- Immunotherapy
Background:
- Renal cell carcinoma (RCC) is the most common kidney cancer.
- While localized RCC is curable with surgery, recurrence with metastatic disease remains a challenge.
- Effective treatments are needed to improve survival by reducing RCC recurrence risk.
Approach:
- This review examines perioperative therapies for RCC.
- Focus is placed on recent clinical trials of immune checkpoint inhibitors (ICIs).
Key Points:
- Immune checkpoint inhibitors (ICIs) have transformed advanced RCC treatment.
- Four perioperative ICI trials for RCC have been reported.
- The Keynote-564 trial demonstrated a disease-free survival benefit with adjuvant pembrolizumab in resected RCC.
Conclusions:
- Patients with resected RCC face a risk of recurrence.
- Adjuvant pembrolizumab is a potential perioperative treatment option.
- Overall survival data for adjuvant pembrolizumab are pending.
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