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Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation,

Moritz Schüssler1, Kerstin Schott1, Nina Verena Fuchs1

  • 1Host-Pathogen Interactions, Paul-Ehrlich-Institut , Langen, Germany.

Mbio
|October 6, 2023
PubMed
Abstract

Keywords:
CRISPR/Cas9HIV-1SAMHD1gene editinginnate immunityrestriction factor

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Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...