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Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
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Multicomponent cyclization with azides to synthesize N-heterocycles.
Hong Guo1, Bei Zhou1, Jingjing Chang1
1College of Science, China Agricultural University, Beijing 100193, China. zhangzhh@cau.edu.cn.
Organic & Biomolecular Chemistry
|October 6, 2023
Summary
This review highlights multicomponent reactions (MCRs) using organic azides for synthesizing N-heterocyclic compounds. These efficient methods offer diverse and complex molecular scaffolds, expanding synthetic chemistry applications.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
- Synthetic Chemistry
Background:
- Heterocyclic compounds are vital in biology and industry.
- Organic azides offer unique reactivity for heterocycle synthesis.
- Multicomponent reactions (MCRs) provide efficient access to complex molecular scaffolds.
Purpose of the Study:
- To review the application of MCRs for N-heterocycle preparation.
- To highlight the utility of organic azides in these MCRs.
- To underscore the ongoing development in this synthetic area.
Main Methods:
- Review of literature on MCRs involving organic azides.
- Categorization of reactions based on azide utilization.
- Analysis of synthesized N-heterocyclic systems.
Main Results:
- Demonstration of diverse N-heterocycles synthesized via MCRs.
- Showcasing the versatility of organic azides in MCRs.
- Identification of established and emerging synthetic pathways.
Conclusions:
- MCRs employing organic azides are powerful tools for N-heterocycle synthesis.
- These methods offer novelty, diversity, and complexity in heterocyclic chemistry.
- Further exploration of MCR pathways for N-heterocycles is warranted.
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