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Related Experiment Videos

Ritodrine pharmacokinetics.

B R Kuhnert, T L Gross, P M Kuhnert

    Clinical Pharmacology and Therapeutics
    |December 1, 1986
    PubMed
    Summary
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    Ritodrine, used tocolytically, is extensively metabolized in mothers and neonates, with most excreted as conjugates. This study details ritodrine

    Area of Science:

    • Pharmacology
    • Perinatal Medicine
    • Analytical Chemistry

    Background:

    • Limited data exists on ritodrine pharmacology during the peripartum period.
    • Ritodrine is a beta-2 adrenergic agonist used to inhibit preterm labor.

    Purpose of the Study:

    • To investigate the pharmacokinetics of ritodrine in mothers and neonates when labor is not inhibited despite treatment.
    • To quantify free and conjugated ritodrine in maternal and infant plasma and urine.

    Main Methods:

    • High-performance liquid chromatography (HPLC) with electrochemical detection was used.
    • Plasma and urine samples were collected from 26 mothers and 13 neonates.
    • Ritodrine levels were measured within 24 hours of delivery.

    Main Results:

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    • Maternal ritodrine exhibited a rapid distribution phase (t1/2 = 32 min) followed by a prolonged elimination phase (t1/2 = 17 hours).
    • Approximately 76% of ritodrine excreted by mothers was in conjugated form.
    • About 90% of ritodrine excreted by neonates was also in conjugated form.

    Conclusions:

    • Ritodrine undergoes significant metabolism and conjugation in both mothers and neonates.
    • Understanding ritodrine's pharmacokinetic profile is crucial for managing treatment failures in preterm labor.