Related Experiment Video
Updated: Jul 14, 2025
04:55
A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice
Published on: May 11, 2022
3.9K
From drab to Fab; PLP1's fit is redressed for MS
Alexandra C Bayer1, Kevin C O'Connor1
1Departments of Immunobiology and Neurology, Yale University School of Medicine, New Haven, CT 06520, USA.
Science Immunology
|October 6, 2023
Abstract:
Curated expression of proteolipid protein 1 (PLP1) is essential for multiple sclerosis-derived autoantibody recognition.
Related Concept Videos
01:35Long-term Potentiation
55.3K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
55.3K
01:15Parkinson's Disease: Overview
587
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
587