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The need for an intersectionality framework in precision medicine research.

Maya Sabatello1, Gregory Diggs-Yang2, Alicia Santiago3

  • 1Center for Precision Medicine and Genomics, Department of Medicine, New York, NY, USA; Division of Ethics, Department of Medical Humanities and Ethics, New York, NY, USA.

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This summary is machine-generated.

Precision medicine needs diverse participants for equitable health. An intersectional approach considering multiple factors beyond race and ethnicity is crucial for inclusive research and improved outcomes.

Keywords:
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Area of Science:

  • Biomedical Research
  • Health Equity
  • Precision Medicine

Background:

  • Precision medicine aims to improve generalizability and health equity by increasing participation of underrepresented groups.
  • Key challenges include distrust, representation issues, translational difficulties, and inadequate community engagement.
  • Current efforts often focus narrowly on single demographic factors, neglecting intersecting identities.

Purpose of the Study:

  • To advocate for a more nuanced, intersectional framework in precision medicine research.
  • To address gaps in understanding how overlapping marginalizations impact research participation and outcomes.
  • To propose strategies for equitable benefits from precision medicine for diverse communities.

Main Methods:

  • Review of existing literature on precision medicine research participation and equity.
  • Analysis of limitations in current demographic-focused approaches.
  • Development of an intersectional framework for data collection, analysis, and implementation.

Main Results:

  • Overlapping layers of marginalization (e.g., race, disability, gender identity, socioeconomic status) significantly impact research participation.
  • Single-dimensional demographic criteria are insufficient for capturing the complexity of underrepresentation.
  • An intersectional approach is necessary to enhance cohort diversity and research responsiveness.

Conclusions:

  • Moving beyond single demographic factors is essential for advancing precision medicine research.
  • An intersectional framework promotes more inclusive and equitable research practices.
  • Implementing such a framework can help ensure precision medicine benefits diverse and heterogeneous communities.