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Diagnostic and prognostic value of H-ficolin for functionally relevant coronary artery disease

Ganna Isayeva1, Eliska Potlukova2, Klara Rumora1

  • 1Cardiovascular Research Institute Basel (CRIB), University Heart Center, University Hospital Basel, University of Basel, Switzerland.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|October 6, 2023
PubMed

Insights

H-ficolin, a complement system protein, showed no diagnostic or prognostic value for functionally relevant coronary artery disease (fCAD). This study found no significant association between H-ficolin levels and fCAD diagnosis or cardiovascular outcomes.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Complement System

Background:

  • H-ficolin initiates the lectin pathway of the complement system.
  • Investigating H-ficolin's role in coronary artery disease (CAD) is crucial for understanding cardiovascular health.
  • The diagnostic and prognostic capabilities of H-ficolin in functionally relevant CAD (fCAD) require further elucidation.

Purpose of the Study:

  • To evaluate the diagnostic and prognostic utility of H-ficolin in patients with suspected fCAD.
  • To explore potential determinants of H-ficolin levels in this patient cohort.

Main Methods:

  • Utilized myocardial perfusion imaging and coronary angiography to diagnose fCAD in 1,571 patients.
  • Measured H-ficolin levels using immunoassay at rest, peak stress, and 2 hours post-stress.
  • Assessed cardiovascular death and non-fatal myocardial infarction over a 5-year follow-up period.

Main Results:

  • H-ficolin levels did not differ significantly between patients with and without fCAD (AUC 0.53).
  • H-ficolin was not a predictor of cardiovascular events in the overall cohort.
  • A potential association was observed between H-ficolin and non-fatal myocardial infarction in patients without fCAD.

Conclusions:

  • H-ficolin concentration lacks diagnostic and prognostic value for patients undergoing evaluation for fCAD.
  • No significant correlation was found between H-ficolin and the presence of fCAD.
  • Further research may be needed to clarify the specific role of H-ficolin in certain subgroups, such as patients without fCAD.
Abstract

Keywords:
Functionally relevant coronary artery diseaseH-ficolinThe complement immune system

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