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Updated: Jul 14, 2025

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes

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Steroidogenic Factor-1 form and function: From phospholipids to physiology.

Alexis N Campbell¹, Woong Jae Choi², Ethan S Chi²

¹Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, 37232, USA; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.

Advances in Biological Regulation

|October 6, 2023

Summary

This summary is machine-generated.

Steroidogenic Factor-1 (SF-1) regulates key bodily functions and is linked to diseases like adrenal cancer. This review details SF-1

Keywords:

Ad4BP integrative structural biology of steroidogenesis and gene expression Nuclear phosphoinositide function R255L polymorphism

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Last Updated: Jul 14, 2025

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes

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Published on: March 14, 2021

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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

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Published on: June 3, 2016

Area of Science:

Molecular Biology
Endocrinology
Structural Biology

Background:

Steroidogenic Factor-1 (SF-1) is a nuclear receptor crucial for endocrine system development and function.
SF-1 plays a vital role in the hypothalamic-pituitary-adrenal and gonadal axes.
Dysregulation of SF-1 is implicated in diseases such as endometriosis and adrenocortical carcinoma.

Conclusions:

SF-1 is a key regulator in physiology and disease, especially in adrenal cancer.
Understanding SF-1's structural biology and regulatory network is critical for therapeutic development.
This review consolidates current knowledge on SF-1's form and function in health and disease.