[Optimal processing technology of Zhangbang vinegar-processed Olibanum with multi-indicator-response surface...

Area of Science:

• Traditional Chinese Medicine processing techniques.
• Phytochemistry and natural product analysis.
• Pharmacology and anticoagulant activity.

Context:

• Olibanum (Boswellia species) is a traditional medicinal resin with various therapeutic properties.
• Traditional processing methods for Olibanum can influence its chemical composition and efficacy.
• Optimizing processing is crucial for maximizing the therapeutic potential of herbal medicines.

Purpose:

• To optimize the processing technology for Zhangbang vinegar-processed Olibanum.
• To investigate the in vitro anticoagulant activity of the optimized product.
• To establish a stable and feasible processing method for Olibanum.

Summary:

• A multi-index response surface methodology and analytical hierarchy process were used to optimize Zhangbang vinegar processing of Olibanum.
• The optimal processing involved specific stir-frying, burning, rice vinegar spraying, and steaming parameters.
• In vitro studies demonstrated that vinegar-processed Olibanum significantly prolonged activated partial thromboplastin time, thrombin time, and prothrombin time compared to raw Olibanum.

Impact:

• The optimized Zhangbang vinegar processing method is stable, feasible, and enhances the anticoagulant properties of Olibanum.
• This research provides a scientific basis for the further development and clinical application of processed Olibanum products.
• The findings support the utilization of Olibanum slices with improved pharmacological activity.