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Decreased intracellular water is associated with sarcopenic obesity in chronic haemodialysis patients

Maolu Tian1,2,3, Jing Yuan1,2, Fangfang Yu1

  • 1Department of Nephrology, Guizhou Provincial People's Hospital, Guiyang, China.

BMC Geriatrics
|October 6, 2023
PubMed

Insights

Low intracellular water (ICW) is linked to sarcopenic obesity in chronic hemodialysis (HD) patients. Measuring ICW may help identify patients at risk for this condition.

Area of Science:

  • Nephrology
  • Clinical Nutrition
  • Body Composition Analysis

Background:

  • Sarcopenic obesity is a growing concern in patients undergoing chronic hemodialysis (HD).
  • Body composition abnormalities, including intracellular water (ICW) depletion, are common in this population.
  • Understanding the relationship between ICW and sarcopenic obesity is crucial for risk stratification and management.

Purpose of the Study:

  • To investigate the association between intracellular water (ICW) levels and the prevalence of sarcopenic obesity among adult patients on chronic HD.
  • To determine if decreased ICW is an independent risk factor for sarcopenic obesity in this patient group.

Main Methods:

  • A multicenter, cross-sectional study involving 3354 adult chronic HD patients.
  • Sarcopenic obesity diagnosed using the revised Asian Working Group's definition for sarcopenia and body fat percentage for obesity.
  • Body composition assessed via bioimpedance spectroscopy; data analyzed using multiple logistic regression and stratified analyses.

Main Results:

  • Sarcopenic obesity was diagnosed in 752 (22.5%) of the participants.
  • A significantly higher prevalence of sarcopenic obesity was observed in patients with low ICW compared to those with high ICW (41.3% vs. 3.0%).
  • Decreased ICW was independently associated with sarcopenic obesity, even after adjusting for confounding factors. Specific ICW cut-off values were identified for males (19.1 kg) and females (14.5 kg).

Conclusions:

  • Reduced intracellular water (ICW) is an independent risk factor for sarcopenic obesity in patients undergoing chronic hemodialysis.
  • Bioimpedance spectroscopy measurement of ICW offers a non-invasive and potentially valid method for identifying HD patients at risk of sarcopenic obesity.
Abstract

Keywords:
HaemodialysisIntracellular waterSarcopenic obesity

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