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Suprofen-induced acute renal failure
Drug Intelligence & Clinical Pharmacy
|November 1, 1986
Summary
A young adult experienced acute flank pain and reversible kidney failure after taking suprofen. Kidney function normalized after discontinuing the medication, highlighting a potential adverse drug reaction.
Area of Science:
- Nephrology
- Clinical Pharmacology
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain relief.
- NSAIDs can cause renal adverse effects, particularly in susceptible individuals.
Observation:
- A case of acute flank pain and renal failure in a young adult is reported.
- The patient had taken three doses of suprofen, an NSAID.
Findings:
- Elevated blood urea nitrogen and serum creatinine levels indicated significant renal impairment.
- Renal function returned to normal after cessation of suprofen therapy, demonstrating reversibility.
Implications:
- This case highlights the potential for suprofen to induce acute kidney injury.
- Clinicians should be aware of NSAID-associated nephrotoxicity and monitor renal function in patients using these drugs.