Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.7K
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

2.7K
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
2.7K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

6.4K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
6.4K
Notch Signaling Pathway03:14

Notch Signaling Pathway

4.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.3K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated Metabolomic and Genomic Insights into Amino Acid Incorporation Within the Hybrid Polyketide-Alkaloid Antibiotic TLN-05220.

ACS chemical biology·2026
Same author

Integrated metabolomic and genomic insights into amino acid incorporation within the hybrid polyketide-alkaloid antibiotic TLN-05220.

bioRxiv : the preprint server for biology·2025
Same author

Regulation of epithelial-mesenchymal transition by tumor microenvironmental signals and its implication in cancer therapeutics.

Seminars in cancer biology·2022
Same author

[Construct cosmid libraries by isolating large genomic DNA fragments from Monascus ruber].

Wei sheng wu xue bao = Acta microbiologica Sinica·2010
Same author

[Correlation between MR diffusion weighted imaging with malignant degree of rabbit liver VX2 tumor models].

Zhonghua yi xue za zhi·2010
Same author

[Immune response in BALB/c mice immunized with BCG expressing HBV truncated C gene and preS1 gene].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology·2010

Related Experiment Video

Updated: Jul 14, 2025

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.5K

Mechanotransduction pathways in regulating epithelial-mesenchymal plasticity.

Calista A Horta1, Khoa Doan1, Jing Yang2

  • 1Department of Pharmacology, Moores Cancer Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.

Current Opinion in Cell Biology
|October 7, 2023
PubMed
Summary

The extracellular matrix (ECM) stiffness promotes cancer cell invasion and metastasis by triggering epithelial-mesenchymal transition (EMT) through mechanotransduction. Understanding these mechanosensors and responders is key to developing new cancer therapies.

More Related Videos

Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

35.8K
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

13.0K

Related Experiment Videos

Last Updated: Jul 14, 2025

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.5K
Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

35.8K
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

13.0K

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Cancer Research

Background:

  • The extracellular matrix (ECM) provides structural support and mediates cell signaling.
  • Mechanical forces from the ECM regulate biological processes, including cell behavior.
  • Epithelial-mesenchymal transition (EMT) is crucial for cell migration and invasion in cancer metastasis.

Purpose of the Study:

  • To highlight innovative approaches for studying mechanotransduction.
  • To summarize newly discovered mechanisms of mechanosensor and responder regulation of EMT.
  • To emphasize the role of ECM mechanical force in tumor invasion and metastasis.

Main Methods:

  • Review of recent studies utilizing novel approaches to investigate mechanotransduction.
  • Analysis of cellular signaling pathways affected by ECM stiffness.
  • Identification of key mechanosensors and responders involved in EMT.

Main Results:

  • Increasing ECM stiffness promotes EMT in carcinoma cells via mechanotransduction.
  • Mechanical force exerted by the ECM is a critical regulator of tumor invasion and metastasis.
  • New mechanisms by which mechanosensors and responders control EMT during tumor progression have been identified.

Conclusions:

  • The mechanical properties of the ECM significantly influence cancer progression.
  • Targeting mechanotransduction pathways offers potential therapeutic strategies for cancer metastasis.
  • Further research into ECM-cell interactions is vital for understanding and treating cancer.