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Area of Science:

  • Gerontology
  • Pharmacology
  • Urology

Background:

  • Metformin, a common diabetes medication, has shown potential in animal models to improve bladder overactivity.
  • Overactive bladder (OAB) is a common condition affecting older adults, often managed with medication.

Purpose of the Study:

  • To investigate the association between metformin use and the rate of overactive bladder (OAB) medication use in elderly patients with type 2 diabetes mellitus (DM2).

Main Methods:

  • A retrospective nested case-control cohort study was conducted using large healthcare administrative databases.
  • Patients with DM2 aged 69 years and older were included, with cases receiving OAB medication prescriptions matched to controls.
  • Metformin prescription prior to OAB medication was assessed as the exposure, with adjusted odds ratios calculated.

Main Results:

  • A cohort of 2,233,084 patients with DM2 was analyzed, identifying 16,549 cases and 64,171 controls.
  • Metformin use showed a slight positive association with OAB medication use (aOR=1.07, 95% CI=1.03-1.12).
  • This association persisted until cumulative metformin supply exceeded 2220 days, after which no significant association was found.

Conclusions:

  • Metformin use in older patients with DM2 is associated with a slightly increased rate of OAB medication use.
  • The findings do not support a protective role for metformin in preventing OAB in this population.
  • No association was observed with prolonged metformin use (>2220 days).