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An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
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Catheter-associated urinary tract infection and urinary tract abnormalities in young children: A retrospective study

Hiroyuki Oikawa1, Yuya Morooka2, Munehiro Furuichi1

  • 1Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan, Tokyo, Japan.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|October 7, 2023
PubMed

Insights

Urinary tract abnormalities increase the risk of catheter-associated urinary tract infections (CAUTI) in young children. This study found that abnormal urogenital images significantly correlated with CAUTI development in pediatric intensive care unit patients.

Area of Science:

  • Pediatric critical care medicine
  • Infectious disease epidemiology
  • Urology

Background:

  • Catheter-associated urinary tract infections (CAUTI) are a significant concern in pediatric intensive care units (PICU) and high care units (HCU).
  • Limited research exists on the contribution of underlying urinary tract abnormalities to CAUTI development in young children.
  • This study addresses the knowledge gap by investigating the association between CAUTI and urogenital abnormalities.

Purpose of the Study:

  • To determine if urinary tract abnormalities are associated with an increased risk of developing CAUTI in children under six years old.
  • To identify risk factors contributing to CAUTI in hospitalized pediatric patients.

Main Methods:

  • Retrospective analysis of pediatric patients (<6 years) with CAUTI admitted to PICU/HCU between April 2018 and July 2022.
  • Abdominal imaging studies were performed on all CAUTI patients.
  • Propensity score matching and multivariable logistic regression were used to compare cases and controls and analyze risk factors.

Main Results:

  • Abnormal urogenital images were significantly associated with CAUTI development (OR 5.30 before matching, OR 3.44 after matching).
  • Prolonged catheterization (>10 days) was also a significant risk factor for CAUTI (OR 2.76 before matching, OR 3.44 after matching).
  • CAUTI in young children in PICU/HCU showed a significant association with urinary tract imaging abnormalities.

Conclusions:

  • Urinary tract malformations, in addition to catheter presence, are implicated in the development of CAUTI in young children.
  • Early identification of urinary tract abnormalities may be crucial for CAUTI prevention strategies in pediatric critical care settings.
Abstract

Keywords:
Catheter-associated urinary tract infectionHospital acquired infectionPediatric intensive care unitUrinary tract abnormalitiesUrinary tract infection

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