Related Experiment Video

Updated: Jul 14, 2025

Isolation and Analysis of Traceable and Functionalized Extracellular Vesicles from the Plasma and Solid Tissues
09:57

Isolation and Analysis of Traceable and Functionalized Extracellular Vesicles from the Plasma and Solid Tissues

Published on: October 17, 2022

2.1K

The multiple frontiers in the study of extracellular vesicles produced by fungi

Marcio L Rodrigues1, Robin C May2, Guilhem Janbon3

  • 1Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba, PR, 81310-020, Brazil; Microbiology Institute, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

Microbes and Infection
|October 7, 2023
PubMed

Insights

Fungal extracellular vesicles (EVs) play key roles in biofilm formation and antifungal resistance. These EVs also hold potential for developing new fungal vaccines and fostering global research collaboration.

Area of Science:

  • Mycology
  • Cell Biology
  • Immunology

Background:

  • Extracellular vesicles (EVs) produced by fungi are increasingly recognized as critical mediators of fungal biology.
  • Fungal EVs have been studied for approximately ten years.

Purpose of the Study:

  • To review the multifaceted roles of fungal EVs.
  • To highlight their involvement in biofilm formation, antifungal resistance, and immunogen release.
  • To discuss their contribution to international scientific collaboration and understanding of fungal biology.

Main Methods:

  • Literature review and synthesis of existing research on fungal EVs.
  • Analysis of the functional implications of EVs in fungal pathogenesis and host interactions.

Main Results:

  • Fungal EVs are implicated in the development and structural integrity of fungal biofilms.
  • EVs contribute to the emergence of antifungal resistance in fungal populations.
  • Fungal EVs can present immunogenic molecules, suggesting potential as vaccine candidates.

Conclusions:

  • Fungal EVs are significant players in fungal pathogenesis, host immune response, and therapeutic strategies.
  • Further research into fungal EVs can advance vaccine development and international cooperation in mycology.
Keywords:
AntifungalsExtracellular vesiclesFungiVaccine

More Related Videos

Freeze-Fracture Electron Microscopy for Extracellular Vesicle Analysis11:30

Freeze-Fracture Electron Microscopy for Extracellular Vesicle Analysis

Published on: September 16, 2022

3.8K
Characterizing Extracellular Vesicles from Biological Fluids05:07

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

396

Related Concept Videos

Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
8.6K
Overview of Exosomes01:36

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K
Exocytosis00:51

Exocytosis

Exocytosis is used to release material from cells. Like other bulk transport mechanisms, exocytosis requires energy.
66.7K