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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Jul 14, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Ciliary body size in chronic angle-closure glaucoma.

Jost B Jonas1,2,3, Rahul A Jonas4, Shefali B Jonas5

  • 1Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Kutzerufer 1, 68167, Mannheim, Germany. Jost.Jonas@medma.uni-heidelberg.de.

Scientific Reports
|October 7, 2023
PubMed
Summary
This summary is machine-generated.

The ciliary body stroma (CBS) is significantly smaller in eyes with a closed anterior chamber angle compared to those with open angles. This size difference in CBS may impact aqueous humor outflow pathways.

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Area of Science:

  • Ophthalmology
  • Anatomy
  • Histomorphometry

Background:

  • The morphology of the anterior chamber angle influences intraocular pressure and ocular health.
  • Understanding the ciliary body stroma's (CBS) size in relation to anterior chamber angle morphology is crucial for diagnosing and managing various ocular conditions.

Purpose of the Study:

  • To investigate the relationship between the size of the ciliary body stroma (CBS) and the morphology of the anterior chamber angle in human eyes.
  • To determine if CBS size differs between eyes with open and closed anterior chamber angles.

Main Methods:

  • Histomorphometric analysis of 107 enucleated human eyes.
  • Categorization of eyes into open anterior chamber angle (68 eyes) and closed, endothelialized anterior chamber angle (39 eyes) groups.
  • Measurement of maximal and minimal CBS width, and maximal ciliary muscle height.

Main Results:

  • Eyes with a closed anterior chamber angle exhibited significantly smaller maximal CBS width (59 ± 179 µm) and minimal CBS width (17 ± 55 µm) compared to eyes with open angles (541 ± 210 µm and 214 ± 107 µm, respectively).
  • Maximal ciliary muscle height was also significantly smaller in the angle-closure group (293 ± 111 µm) than in the open-angle group (593 ± 557 µm).
  • Maximal CBS width and minimal CBS width were positively correlated with an open anterior chamber angle and axial length.

Conclusions:

  • The ciliary body stroma (CBS) is markedly smaller in eyes with a chronically closed, endothelialized anterior chamber angle compared to eyes with open angles.
  • Angle closure may impede aqueous humor access to the trabecular meshwork and ciliary body, potentially reducing uveoscleral and uveovortex outflow.