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Acute decrease in progesterone and increase in estrogen secretion caused by relaxin during late pregnancy in beef

A I Musah, C Schwabe, L L Anderson

    Endocrinology
    |January 1, 1987
    PubMed
    Summary
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    Porcine relaxin administered to beef heifers near term significantly lowered progesterone and increased estrone and estradiol. This suggests relaxin has potent luteolytic effects in cattle.

    Area of Science:

    • Reproductive Endocrinology
    • Veterinary Medicine
    • Animal Science

    Background:

    • Relaxin plays a crucial role in pregnancy and parturition across species.
    • The effects of exogenous relaxin on late-term pregnancy hormones in cattle are not well-defined.
    • Understanding relaxin's impact is vital for managing beef cattle reproduction.

    Purpose of the Study:

    • To investigate the effects of porcine relaxin administration on progesterone, estrone (E1), and 17 beta-estradiol (17 beta-E2) secretion in late-term pregnant beef heifers.
    • To determine the pharmacokinetic profile of immunoreactive relaxin after intramuscular and cervical os administration.

    Main Methods:

    • Purified porcine relaxin was administered intramuscularly (RLX-IM) or into the cervical os (RLX-OS) to pregnant beef heifers (n=2 each).

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  • Control groups received placebo (PBS or gel-PBS).
  • Peripheral blood plasma was analyzed for relaxin, progesterone, E1, and 17 beta-E2 levels at various time points.

    • Main Results:

    • Relaxin administration induced a rapid increase in plasma relaxin levels, peaking between 23-31 ng/ml.
    • A significant decrease in progesterone was observed within 90 minutes post-administration, followed by significant increases in E1 and 17 beta-E2.
    • Relaxin administration accounted for substantial variability in progesterone (70%), E1 (73%), and 17 beta-E2 (58%) levels.

    Conclusions:

    • Pharmacological doses of relaxin induce acute luteolysis and depress progesterone secretion in late-term pregnant beef heifers.
    • Relaxin administration also stimulates the secretion of E1 and 17 beta-E2, suggesting a role in initiating parturition.
    • These findings highlight potential direct or indirect mechanisms of relaxin's luteolytic action in cattle.