Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

357
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
357
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

2.3K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.3K
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

5.6K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of antioxidant and micronutrient intake on varicocele-associated infertility: a retrospective analysis.

Frontiers in nutrition·2026
Same author

Association of Fibrosis-Related Gene Expression Profiles in Benign Ureteral Stricture Tissue With Restenosis After Ureteroplasty.

Archivos espanoles de urologia·2026
Same author

Serpine1 regulates Th17 cell differentiation and exacerbates IMQ-induced skin inflammation.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

<i>RBFOX1</i> Dysfunction Unlocks <i>APOE4</i>-Associated Microglial Genesis and Exacerbates Alzheimer's Pathology in Human Cerebral Organoids.

Exploration (Beijing, China)·2026
Same author

Proteome profiles of esophageal squamous cell carcinoma tie mitochondrial complex I to immunotherapy.

EMBO molecular medicine·2026
Same author

Modified technique for dissection of working space in retroperitoneal laparoscopic surgery: A step-by-step guide.

BJUI compass·2025

Related Experiment Video

Updated: Jul 14, 2025

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.5K

Manganese Exacerbates ConA-Induced Liver Inflammation via the cGAS-STING Signaling Pathway.

Kaidireya Saimaier1, Sanxing Han1, Jie Lv1

  • 1Putuo People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.

Inflammation
|October 8, 2023
PubMed
Summary

Excess manganese worsens autoimmune hepatitis (AIH) by activating the cGAS-STING inflammatory pathway. This finding offers new insights into AIH treatment and prognosis, highlighting the role of trace element dysregulation.

Keywords:
autoimmune hepatitiscGAS-STINGliver inflammationmanganese

More Related Videos

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice
11:38

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

Published on: July 22, 2014

13.4K
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

52.4K

Related Experiment Videos

Last Updated: Jul 14, 2025

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.5K
In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice
11:38

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

Published on: July 22, 2014

13.4K
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

52.4K

Area of Science:

  • Hepatology
  • Immunology
  • Toxicology

Background:

  • Trace element dysregulation is linked to liver dysfunction.
  • Elevated manganese levels are observed in liver diseases, potentially worsening damage.
  • Mechanisms of manganese-induced liver injury require further elucidation.

Purpose of the Study:

  • Investigate the impact of excess manganese on autoimmune hepatitis (AIH).
  • Elucidate the underlying mechanisms of manganese-induced liver injury in AIH.

Main Methods:

  • Utilized a mouse model of autoimmune hepatitis (AIH) with Concanavalin A (ConA) induction.
  • Performed transcriptomic analysis to identify molecular pathways affected by manganese.
  • Conducted experimental validation of key signaling pathways and inflammatory markers.

Main Results:

  • Manganese exacerbates liver damage in ConA-induced AIH mouse models.
  • Transcriptomic data indicates manganese enhances inflammatory signaling and the hepatic inflammatory microenvironment.
  • Manganese activates the cGAS-STING signaling pathway, leading to increased pro-inflammatory factors (IFN-γ, TNF-α, IL-6).

Conclusions:

  • Manganese overload promotes AIH progression through cGAS-STING-mediated inflammation.
  • This study provides a novel perspective on AIH pathogenesis and potential therapeutic targets.
  • Understanding manganese's role in inflammation is crucial for AIH treatment and prognosis.