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Manganese Exacerbates ConA-Induced Liver Inflammation via the cGAS-STING Signaling Pathway

Kaidireya Saimaier1, Sanxing Han1, Jie Lv1

  • 1Putuo People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.

Inflammation
|October 8, 2023
PubMed

Insights

Excess manganese worsens autoimmune hepatitis (AIH) by activating the cGAS-STING inflammatory pathway. This finding offers new insights into AIH treatment and prognosis, highlighting the role of trace element dysregulation.

Area of Science:

  • Hepatology
  • Immunology
  • Toxicology

Background:

  • Trace element dysregulation is linked to liver dysfunction.
  • Elevated manganese levels are observed in liver diseases, potentially worsening damage.
  • Mechanisms of manganese-induced liver injury require further elucidation.

Purpose of the Study:

  • Investigate the impact of excess manganese on autoimmune hepatitis (AIH).
  • Elucidate the underlying mechanisms of manganese-induced liver injury in AIH.

Main Methods:

  • Utilized a mouse model of autoimmune hepatitis (AIH) with Concanavalin A (ConA) induction.
  • Performed transcriptomic analysis to identify molecular pathways affected by manganese.
  • Conducted experimental validation of key signaling pathways and inflammatory markers.

Main Results:

  • Manganese exacerbates liver damage in ConA-induced AIH mouse models.
  • Transcriptomic data indicates manganese enhances inflammatory signaling and the hepatic inflammatory microenvironment.
  • Manganese activates the cGAS-STING signaling pathway, leading to increased pro-inflammatory factors (IFN-γ, TNF-α, IL-6).

Conclusions:

  • Manganese overload promotes AIH progression through cGAS-STING-mediated inflammation.
  • This study provides a novel perspective on AIH pathogenesis and potential therapeutic targets.
  • Understanding manganese's role in inflammation is crucial for AIH treatment and prognosis.
Keywords:
autoimmune hepatitiscGAS-STINGliver inflammationmanganese

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