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Successful prenatal treatment with continuous chronic maternal hyperoxygenation therapy in hypoplastic left heart in

Gokhan Bolluk1, Aylin Oztarhan2, Cagdas Vural3

  • 1Maternal-Fetal Medicine Division, Cam Sakura City Hospital, Health Sciences University Istanbul, İstanbul, Türkiye.

Echocardiography (Mount Kisco, N.Y.)
|October 8, 2023
PubMed

Maternal hyperoxygenation (MH) has been studied as a diagnostic tool to evaluate pulmonary vasculature and as a treatment option to improve the growth of fetal left heart in fetuses with left-sided cardiac defects. Chronic maternal hyperoxygenation (CMH) therapy leads to an improvement in fetal pulmonary blood flow resulting in an enhanced venous return to the left heart with increased gestational age. With this manipulation it is anticipated to augment blood flow directed remodeling of the left heart structures and to improve left heart growth spanning from the mitral valve to the aortic isthmus. However, there are concerns about CMH therapy with regard to fetal complications with growth restriction and fetal brain development. Now, with two successful cases we try to discuss this fetal treatment option and related concerns.

Keywords:
chronic maternal hyperoxygenationcongenital heart defectsfetal therapyhypoplastic left heart

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