Naturally occurring nonneoplastic histopathological lesions in the female SENCAR mouse

Area of Science:

• Toxicology and Pathology
• Animal Models in Research

Background:

• Spontaneous lesions in animal models can impact toxicological study outcomes.
• Understanding baseline lesion frequencies is crucial for accurate bioassay interpretation.

Purpose of the Study:

• To survey and characterize naturally occurring lesions in female SENCAR mice.
• To identify common lesion sites and types in mice used for short-term bioassays.

Main Methods:

• Necropsy was performed on female SENCAR mice utilized in short-term bioassays.
• Gross lesions were examined in target organs and other tissues.
• Histopathological evaluation of identified lesions was conducted.

Main Results:

• Naturally occurring lesions were observed in various organs and tissues.
• The genitourinary system was the most frequent site for observed lesions.
• Commonly identified genitourinary lesions included cystic ovaries, cystic endometrial hyperplasia, and glomerulonephritis.

Conclusions:

• Female SENCAR mice exhibit a range of spontaneous lesions, predominantly in the genitourinary system.
• These findings provide essential baseline data for interpreting toxicological studies in this model.
• Awareness of these common lesions is vital for accurate risk assessment in SENCAR mouse bioassays.