Related Experiment Video
Updated: Jul 14, 2025
08:33
Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
Published on: November 17, 2018
13.0K
Drug and gut microbe relationships: Moving beyond antibiotics
Shreyas V Kumbhare1, Inti Pedroso1, Juan A Ugalde2
1Digbi Health, Mountain View, CA, USA.
Drug Discovery Today
|October 8, 2023
Summary
The gut microbiome
Area of Science:
- Microbiology and Pharmacology
- Gut Microbiome Research
- Drug Discovery and Development
Background:
- Microbes were historically viewed as drug producers.
- Current understanding sees microbes as dynamic systems.
- This includes microbes as drugs or targets in precision pharmacology.
Purpose of the Study:
- To review recent findings on drug-microbe interactions in the gut microbiome.
- To highlight four key research areas: drugs for bugs, bugs as drugs, drugs from bugs, and bugs and drugs.
- To provide a future perspective on translational research and diagnostics.
Main Methods:
- Literature review of recent findings on gut microbiome and drug interactions.
- Focus on four distinct research areas within drug-microbe relationships.
- Discussion of future translational research avenues.
Main Results:
- The gut microbiome is a dynamic system with complex drug interactions.
- Research encompasses targeting pathogens, using microbes as therapeutics (probiotics), and utilizing microbial products (postbiotics).
- Additional drug-microbe interactions are being explored.
Conclusions:
- The gut microbiome offers a modifiable system for pharmaceutical interventions.
- Future research should focus on translational applications and companion diagnostics.
- Precision pharmacology leveraging the microbiome is a growing field.
Keywords:
antimicrobial peptides (AMPs)drug discoveryfecal microbiota transplantation (FMT)live biotherapeuticsmicrobial pharmacogenomicsmicrobiomemultiomics integrationphage therapyprobiotics and prebioticstherapeutic targetsMore Related Videos
00:06Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
Published on: August 23, 2019
7.1K
05:58Author Spotlight: Axenic Rearing of Delia antiqua to Detect the Impact of Intestinal Microbes on Its Growth and Development
Published on: December 22, 2023
728
Related Concept Videos
01:29Microorganisms in Medicine and Therapeutics
37
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
37
01:27Combined Effects of Drugs: Synergism
4.0K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
4.0K
01:18Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
136
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
136
01:29Bacterial Flora of the Large Intestine
490
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
490
01:50What is Monogastric Digestion?
71.3K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.3K
01:30Development of Antibiotic Resistance
20
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
20