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Cellulose based composite sponges with oriented porous structure and superabsorptive capacity for quick hemostasis
Xiangfei Yin1, Yinchun Hu2, Min Kang1
1Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, PR China.
International Journal of Biological Macromolecules
|October 8, 2023
Summary
New Ca2+ crosslinked nanocellulose/montmorillonite composite sponges offer rapid hemostasis. These sponges efficiently concentrate blood, promote clotting factor activation, and significantly reduce bleeding in trauma models.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Materials Science
Background:
- Excessive bleeding is a primary cause of mortality in trauma and surgical settings.
- Natural hemostasis involves complex blood clot formation and coagulation cascade activation.
- Developing effective hemostatic agents remains a critical challenge in medicine.
Purpose of the Study:
- To develop a novel hemostatic material inspired by natural hemostasis.
- To investigate the hemostatic efficacy of Ca2+ crosslinked carboxyl nanocellulose (CN)/montmorillonite (MMT) composite (CaCNMMT) sponges.
- To explore the synergistic effects of CN and MMT in promoting rapid blood clotting.
Main Methods:
- Preparation of CaCNMMT sponges using uniform mixing and directional freeze-drying.
- Evaluation of water absorption capacity of CN sponges.
- Assessment of clotting factor activation and hemostatic performance in vitro and in vivo models.
- Measurement of blood clotting index and activated partial thromboplastin time (APTT).
Main Results:
- CaCNMMT sponges demonstrated efficient blood concentration, hemocyte aggregation, and coagulation cascade activation.
- The blood clotting index of CaCNMMT sponges was significantly lower (15.90 ± 0.52 %) compared to CaCN sponges (59.3 ± 1.43 %).
- CaCNMMT sponges exhibited a rapid hemostatic effect in both tail-breaking and liver injury models.
Conclusions:
- CaCNMMT sponges provide a synergistic hemostatic effect by combining the properties of CN and MMT.
- These composite sponges offer a promising new strategy for managing massive hemorrhage.
- The findings suggest a novel application for MMT in hemostatic and trauma treatment fields.
