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lncRNA - Long Non-coding RNAs

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Related Experiment Video

Updated: Jul 14, 2025

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells

Published on: February 22, 2020

Non-coding RNA profile for natural killer cell activity.

Soudeh Ghafouri-Fard¹, Arian Askari², Alireza Zangooie³

¹Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Molecular and Cellular Probes

|October 8, 2023

Summary

This summary is machine-generated.

Dysregulated non-coding RNAs negatively impact natural killer (NK) cell activity and development, contributing to various diseases. This review explores their roles across numerous conditions, offering future research insights.

Keywords:

Long non-coding RNAs NK cells ncRNAs

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Analysis of Human Natural Killer Cell Metabolism

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Published on: June 22, 2020

Area of Science:

Immunology
Molecular Biology
Genetics

Background:

Natural killer (NK) cells are crucial cytotoxic lymphocytes in innate and adaptive immunity.
Disruptions in NK cell function and development are linked to malignant and non-malignant conditions.
Non-coding RNAs (ncRNAs) play a significant role in regulating cellular processes, including immune cell activity.

Purpose of the Study:

To comprehensively review the multifaceted roles of various non-coding RNAs in NK cell activity and development.
To examine the impact of ncRNA dysregulation on NK cells across a wide spectrum of diseases.
To provide insights into future research directions for ncRNA-NK cell interactions.

Main Methods:

Literature review of existing studies on non-coding RNAs and NK cells.
Analysis of ncRNA profiles and their functional impact on NK cell biology.
Synthesis of data from diverse pathological conditions.

Main Results:

Non-coding RNAs, when dysregulated, exert detrimental effects on NK cell function.
Aberrant ncRNA expression is implicated in the pathogenesis of numerous disorders.
Specific ncRNAs influence NK cell development, cytotoxicity, and cytokine production.

Conclusions:

Non-coding RNAs are critical regulators of NK cell homeostasis and function.
Dysregulation of ncRNAs contributes significantly to disease pathogenesis involving NK cells.
Targeting ncRNAs presents a potential therapeutic strategy for NK cell-related disorders.