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Related Experiment Videos

Cadherin cell adhesion molecules with distinct binding specificities share a common structure.

Y Shirayoshi, K Hatta, M Hosoda

    The EMBO Journal
    |October 1, 1986
    PubMed
    Summary

    Calcium-dependent cell adhesion molecules (cadherins) show distinct specificities but share biochemical similarities. Mouse liver E-cadherin and chicken brain N-cadherin share identical molecular weights and amino acid sequences, suggesting a common origin.

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    Area of Science:

    • Molecular Biology
    • Cell Biology
    • Biochemistry

    Background:

    • Cadherins are calcium-dependent cell-cell adhesion molecules.
    • Cadherins are divided into subclasses with distinct tissue distributions and cell-binding specificities.

    Purpose of the Study:

    • To elucidate the biochemical relationship between different cadherin subclasses.
    • To compare mouse liver E-cadherin and chicken brain N-cadherin.

    Main Methods:

    • Comparative analysis of tryptic cleavage patterns.
    • Partial amino acid sequencing of isolated tryptic fragments.
    • Determination of N-terminal amino acid sequences.

    Main Results:

    • E-cadherin and N-cadherin exhibited identical molecular weights.

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  • Both cadherins displayed similar tryptic cleavage patterns.
  • The N-terminal amino acid sequences (first seven residues) were identical.

    • Conclusions:

    • Despite distinct specificities, E-cadherin and N-cadherin share significant biochemical similarities.
    • The findings suggest that cadherins with varying specificities may originate from a common gene.
    • This implies a conserved structural and functional basis for cadherin-mediated adhesion.