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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Behavior Therapy01:22

Behavior Therapy

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Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
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Related Experiment Video

Updated: Jul 14, 2025

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
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Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

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Scar Therapy of Skin.

Jill S Waibel1, Hannah Waibel2, Emily Sedaghat3

  • 1Southern Methodist University.

Facial Plastic Surgery Clinics of North America
|October 8, 2023
PubMed
Summary

Effective scar therapy improves patient quality of life. This review covers diverse treatments, including lasers and early interventions, for various scar types and symptoms like pain and itching.

Keywords:
Acne scarsBurn and trauma scarsEarly intervention scarsLaser-assisted drug delivery scarsScar therapyScarsSurgical scars

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Area of Science:

  • Dermatology and Plastic Surgery
  • Regenerative Medicine
  • Medical Aesthetics

Background:

  • Scars significantly impair patients' quality of life.
  • Numerous treatment modalities exist, including topical, intralesional, surgical, and energy-based devices.
  • Early intervention is crucial for mitigating scar formation.

Purpose of the Study:

  • To provide a comprehensive overview of scar therapy.
  • To highlight innovative treatments like lasers for scar management.
  • To discuss the management of scar-related symptoms such as pruritus, pain, and limited range of motion.

Main Methods:

  • Literature review focusing on scar treatment modalities.
  • Inclusion of recent consensus guidelines on scar management.
  • Emphasis on multimodal and multispecialty approaches.

Main Results:

  • Lasers are a significant innovation for treating all scar types.
  • A wide range of therapies are effective for scar treatment.
  • Management strategies address scar symptoms and functional limitations.

Conclusions:

  • Scar therapy is essential in medicine, requiring a comprehensive approach.
  • Multimodal and multispecialty collaboration is key to optimal scar treatment.
  • Current literature and guidelines support diverse therapeutic options for improved patient outcomes.