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Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Phases of Wound Repair01:28

Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Jul 14, 2025

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
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A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

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Hypertrophic Scar.

Shyla Kajal Bharadia1, Lindsay Burnett2, Vincent Gabriel3

  • 1Cumming School of Medicine, University of Calgary, Foothills Medical Centre, 1403-29 Street Northwest, Calgary, Alberta T2N 2T9, Canada.

Physical Medicine and Rehabilitation Clinics of North America
|October 8, 2023
PubMed
Summary
This summary is machine-generated.

Hypertrophic scars after burns are common and cause itching, pain, and raised skin. This review synthesizes current knowledge on their development, management, and measurement for patients and clinicians.

Keywords:
Burn scarHypertrophic scarScar evolutionScar measurement

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Area of Science:

  • Dermatology
  • Wound Healing
  • Regenerative Medicine

Background:

  • Hypertrophic scars are a frequent and debilitating consequence of burn injuries.
  • These scars present with significant clinical challenges, including pruritus, pain, and restricted mobility due to contracture.
  • Understanding the pathophysiology is crucial for effective treatment strategies.

Purpose of the Study:

  • To provide a comprehensive synthesis of current knowledge regarding hypertrophic burn scars.
  • To cover the clinical and molecular aspects of scar development and evolution.
  • To consolidate information on scar management and measurement techniques.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of clinical observations and molecular mechanisms.
  • Compilation of data on scar assessment tools and therapeutic interventions.

Main Results:

  • Hypertrophic scars exhibit distinct clinical features such as erythema, elevation, and dyschromia.
  • Molecular pathways involving fibroblasts, extracellular matrix deposition, and inflammatory mediators are implicated in scar formation.
  • Various management strategies exist, ranging from conservative treatments to surgical interventions.

Conclusions:

  • Effective management requires a multidisciplinary approach, integrating clinical assessment with an understanding of molecular drivers.
  • Standardized measurement tools are essential for evaluating treatment efficacy.
  • Further research into molecular mechanisms may yield novel therapeutic targets for hypertrophic scar reduction.