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Updated: Jul 14, 2025

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
Brain stimulation for treatment-resistant depression
Aluisio Rodrigues1, Lisiane Martins1, Nivaldo Ribeiro Villela2
1University of São Paulo, Faculty of Medicine, São Paulo, Brazil.
Abstract:
Depression is one of the main public health problems in the world, having a high prevalence and being considered the main cause of disability. An important portion of patients does not respond to treatment with the initial trial of conventional antidepressants in the current depressive episode of moderate to severe intensity, which characterizes treatment-resistant depression. In this context, non-invasive neuromodulation procedures use an electric current or magnetic field to modulate the central nervous system, and they represent a new option for patients with treatment-resistant depression.
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