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MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
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Liquid Biopsy as an Adjunct to Lung Screening Imaging
Nathaniel Deboever1, Edwin J Ostrin2, Mara B Antonoff1
1Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Thoracic Surgery Clinics
|October 8, 2023
Summary
Lung cancer screening using low-dose CT scans has low uptake and high false positives. Blood-based biomarker assays show promise as an adjunct to improve screening accuracy and utilization.
Area of Science:
- Oncology
- Biomarker Discovery
- Medical Diagnostics
Background:
- Current lung cancer screening relies on low-dose computed tomography (LDCT) for high-risk individuals.
- Significant challenges exist, including low patient utilization and a high rate of false-positive results from LDCT.
- Peripheral biomarkers offer a potential alternative or adjunct for cancer detection and monitoring.
Purpose of the Study:
- To evaluate the potential of blood-based biomarker assays.
- To explore their role in enhancing the utilization and accuracy of lung cancer screening protocols.
- To address limitations associated with current screening methods.
Main Methods:
- Review of current literature on peripheral biomarkers for lung cancer.
- Analysis of the potential advantages of blood-based assays over traditional methods.
- Consideration of biomarker assays as an adjunct to low-dose computed tomography screening.
Main Results:
- Peripheral biomarkers demonstrate promise for cancer diagnosis and monitoring.
- Blood-based assays offer potential benefits such as reduced invasiveness and faster turnaround times.
- These assays could complement existing screening modalities.
Conclusions:
- Blood-based biomarker assays represent a promising avenue to improve lung cancer screening.
- Their integration may increase screening participation and diagnostic accuracy.
- Further research and validation are warranted to establish their clinical utility.
