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Updated: Jul 14, 2025

Mesoscopic Optical Imaging of Whole Mouse Heart
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Cardiac multiscale bioimaging: from nano- through micro- to mesoscales.

Elen Tolstik1, Stephan E Lehnart2, Christian Soeller3

  • 1Department of Cardiovascular Pharmacology, Translational Research, Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. Bunsen-Kirchhoff-Strasse 11, 44139 Dortmund, Germany.

Trends in Biotechnology
|October 8, 2023
PubMed
Summary

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Cardiac multiscale bioimaging integrates molecular to organ-level views for heart research. This approach enhances understanding of cardiac physiology and pathology, aiding future medical decisions.

Area of Science:

  • Cardiovascular Research
  • Biomedical Imaging
  • Molecular Cardiology

Background:

  • Cardiac multiscale bioimaging is an emerging field.
  • Understanding the heart requires multi-level analysis, from molecular to organ levels.
  • Current methods face limitations in providing comprehensive cardiac insights.

Purpose of the Study:

  • To establish cardiac multiscale bioimaging as a comprehensive approach for understanding heart function.
  • To integrate nano-, micro-, and mesoscale imaging techniques.
  • To enhance cardiovascular research quality and support medical decision-making through biomolecular information.

Main Methods:

  • Utilizing vibrational spectroscopy and high-resolution microscopy for nano- and micrometer resolution imaging.
Keywords:
cardiac imagingelectron tomographymesoscale cardiac imagingoptogeneticssuper-resolution microscopyvibrational spectroscopy

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  • Employing mesoscale structural investigations.
  • Combining super-resolution deep microscopy with advanced proteomic methods.

    • Main Results:

    • Achieved comprehensive understanding of the heart at various scales.
    • Enabled assessment of molecular processes in cardiac cells and myocardial tissue.
    • Improved understanding of cardiac (patho)physiology through mesoscale investigations.

    Conclusions:

    • Cardiac multiscale bioimaging offers a powerful strategy for advancing cardiovascular research.
    • This integrated approach provides crucial biomolecular information for translational and diagnostic applications.
    • Future medical decision-making will benefit from enhanced insights into cardiac function and disease.