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The Role of Mitochondrial Dysfunction in the Development of Acute and Chronic Hepatitis С

Alexander Blagov1, Vasily Sukhorukov1, Varvara Orekhova1

  • 1Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.

Frontiers in Bioscience (Scholar Edition)
|October 8, 2023
PubMed

Insights

The hepatitis C virus (HCV) alters cellular functions by targeting mitochondrial proteins. This review identifies key viral targets for developing new anti-HCV drugs, differentiating acute and chronic infection strategies.

Area of Science:

  • Virology
  • Cell Biology
  • Biochemistry

Background:

  • Hepatitis C virus (HCV) infection impacts host cellular processes, including antiviral defense, metabolism, and mitochondrial dynamics.
  • HCV achieves this modulation by inhibiting mitochondrial and cellular proteins, leading to pathological changes.

Purpose of the Study:

  • To identify potential mitochondrial protein targets of HCV for novel drug development.
  • To understand how HCV viral strategies differ between acute and chronic phases and their resulting complications.

Main Methods:

  • Literature review and analysis of current research on HCV's interaction with host cellular proteins.
  • Identification and proposal of specific mitochondrial targets based on their role in viral modulation.

Main Results:

  • Key mitochondrial targets proposed include MAVS (antiviral response), Parkin (mitophagy), Drp1 (mitochondrial fission), and ETC complex subunits (oxidative phosphorylation).
  • HCV employs distinct strategies to modulate cellular processes during acute versus chronic infection phases.

Conclusions:

  • Targeting specific mitochondrial proteins offers a promising avenue for developing new therapies against HCV.
  • Understanding the phase-specific viral strategies is crucial for effective therapeutic intervention against HCV complications.
Keywords:
hepatitis Cmitochondriamitochondrial dysfunctionreactive oxygen species

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