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Related Experiment Video

Updated: Jul 14, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Circadian clock crosstalks with autism.

Ekin Yurdakul¹, Yaman Barlas², Kutlu O Ulgen¹

¹Department of Chemical Engineering, Bogazici University, Biosystems Engineering Laboratory, Istanbul, Turkey.

Brain and Behavior

|October 9, 2023

Summary

This study reveals key metabolic pathways linking autism spectrum disorder (ASD) and circadian rhythm disruptions. Understanding the ASD-clock network offers insights into potential early interventions and chronotherapeutic strategies.

Keywords:

ASD bioinformatics circadian rhythmicity neurodevelopmental diseases protein-protein interaction network

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Last Updated: Jul 14, 2025

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Circadian Entrainment of Drosophila Melanogaster

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Published on: June 3, 2020

Area of Science:

Neuroscience
Genetics
Chronobiology

Background:

Autism spectrum disorder (ASD) mechanisms are complex, involving numerous genes and environmental factors like circadian rhythm.
The interplay between ASD and the circadian clock is crucial for understanding neurodevelopmental disorders.

Purpose of the Study:

To investigate the connection between autism and the circadian clock by reconstructing their protein-protein interaction network.
To identify key metabolic pathways and proteins involved in the etiology of ASD influenced by circadian rhythm.

Main Methods:

Reconstruction of the protein-protein interaction network for ASD and circadian rhythm.
Application of graph theory to assess network biological realism.
Gene ontology enrichment analysis to identify significant biological processes.

Main Results:

Identification of critical metabolic pathways including ribosome biogenesis, oxidative stress, and insulin/IGF, Wnt, and mTOR pathways.
Exploration of environmental factors like maternal stress and circadian disruption in ASD development.
Analysis of the ASD-clock network to reveal underlying mechanisms.

Conclusions:

Elucidating the ASD-circadian rhythm relationship provides insights into pathogenesis and etiology.
Findings suggest potential for early intervention and chronotherapeutic strategies for ASD.
Understanding the ASD-clock network is vital for developing novel treatment approaches.