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The Association Between Atherogenic Index of Plasma and No-Reflow Phenomenon in Acute Coronary Syndrome

İbrahim Etem Çelik1, Selçuk Öztürk2, Mikail Yarlıoğlu1

  • 1Department of Cardiology, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Türkiye.

Anatolian Journal of Cardiology
|October 9, 2023
PubMed

Insights

The atherogenic index of plasma (AIP) did not predict no-reflow phenomenon (NRP) in acute coronary syndrome (ACS) patients. Peak troponin T levels, however, independently predicted NRP in this patient group.

Area of Science:

  • Cardiology
  • Biomarkers
  • Interventional Cardiology

Background:

  • The atherogenic index of plasma (AIP) is a key indicator of plasma atherogenicity, with elevated levels associated with increased cardiac event risk.
  • The no-reflow phenomenon (NRP) is a critical complication following percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) patients.
  • Understanding predictors of NRP is crucial for improving patient outcomes after PCI.

Purpose of the Study:

  • To investigate the association between admission atherogenic index of plasma (AIP) and the occurrence of no-reflow phenomenon (NRP) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).

Main Methods:

  • A retrospective analysis was conducted on 884 ACS patients, categorized into NRP (-) (n=662) and NRP (+) (n=186) groups.
  • Atherogenic index of plasma (AIP) was calculated using the formula: log10 (triglyceride/high-density lipoprotein cholesterol ratio).
  • Statistical analyses included receiver operating characteristic (ROC) curve analysis and logistic regression to assess the prognostic value of AIP and peak troponin T for NRP.

Main Results:

  • Patients with NRP exhibited higher admission AIP levels compared to those without NRP.
  • Univariate analysis showed AIP was associated with NRP (OR: 2.46, P=.001), but this association did not hold in multivariate analysis (OR: 2.11, P=.422).
  • Peak troponin T (log10) emerged as an independent prognostic factor for NRP (OR: 0.13, P<.001).

Conclusions:

  • Admission atherogenic index of plasma (AIP) is not a statistically significant predictor of no-reflow phenomenon (NRP) in ACS patients treated with PCI.
  • Peak troponin T (log10) is identified as an independent prognostic parameter for NRP in this population.
  • These findings highlight the importance of troponin T levels in predicting adverse outcomes post-PCI in ACS patients.
Abstract

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