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Published on: July 19, 2018
Elevated triglyceride-glucose index predisposes to the initial episode of peritonitis in chronic peritoneal dialysis
Guiling Liu1, Qiqi Yan1, Ruifeng Wang1
1Department of Nephrology, the Second Affiliated Hospital of Anhui Medical University, Anhui, China.
Objective:
The serum triglyceride-glucose (TyG) index is a marker of inflammation. However, the relationship between TyG index and peritoneal dialysis-related peritonitis (PDRP) is unclear. This study aimed to investigate the potential relationship between the baseline TyG index and the initial episode of PDRP.
Methods:
A total of 208 peritoneal dialysis (PD) patients were enrolled from January 1, 2012, to December 31, 2019 and followed up until December 31, 2022. They were divided into 2 groups according to the median TyG. The primary outcome was the occurrence of the initial episode of PDRP while on PD therapy. Kaplan-Meier curves and Cox regression analyses were used to examine the association between them.
Results:
Eighty-five initial episodes of PDRP were identified. The risk of PDRP was higher in the high-TyG index group (p = 0.030). Multivariate Cox regression analysis showed a higher risk of PDRP in patients with a high TyG index (HR = 1.800, 95% CI 1.511-2.815, p = 0.010).
Conclusion:
The baseline serum TyG index was an independent risk factor for the initial episode of PDRP in chronic PD patients.
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