Related Experiment Video
Updated: Jul 14, 2025

Iris Fixation via External Pentagram Suturing
Published on: May 5, 2022
Clinical Features of Syphilis Patients with Ocular Symptoms as the Initial Manifestation
Haruka Matsumoto1, Shigenari Suzuki1, Mayumi Nagata1
1Department of Ophthalmology, Dokkyo Medical University, Mibu, Japan.
Purpose:
This study aimed to investigate the clinical features of patients with syphilis having ocular symptoms as the initial manifestation.
Patients And Methods:
Eleven patients diagnosed with ocular syphilis at Dokkyo Medical University Hospital and Jichi Medical University Hospital between November 2018 and April 2022 were studied retrospectively.
Results:
Six patients were diagnosed with secondary, three were latent, and one was tertiary stage syphilis. Ten out of 11 patients underwent cerebrospinal fluid analysis, and 1 refused. Nine out of 10 patients tested positive, of which 4 presented with neurological symptoms and the others were asymptomatic. Nine out of 11 patients tested negative for human immunodeficiency virus. Antiluetic therapy was administered to 10 out of 11 patients, which improved or maintained visual acuity at -0.1 logMAR in 9 patients. One patient achieved the best-corrected visual acuity -0.1 logMAR in one eye, whereas the other showed no improvement due to severe chorioretinal degeneration.
Conclusion:
Ocular syphilis presents with various clinical findings and has no significant ocular manifestations without acute syphilitic posterior placoid chorioretinitis. Patients diagnosed with syphilis based on ocular symptoms should undergo cerebrospinal fluid analysis.
More Related Videos
12:23Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
Published on: April 14, 2014
07:50A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
Related Concept Videos
Endocarditis II: Clinical Features of Infective Endocarditis
Sexually Transmitted Infections
Photoreceptors and Visual Pathways
Glaucoma: Overview
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Accessory Structures of the Eye