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Updated: Jul 14, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Acral lentiginous melanoma with multiple bone metastasis: case report
Pei Ting Chen1, Kapilkumar Manvar1, Rashid Chaudhry1
1Division of Hematology/Oncology, Brookdale University Hospital Medical Center, Brooklyn, New York, USA.
Abstract:
Acral lentiginous melanoma (ALM) is a type of melanoma that is traditionally seen on the soles of the feet, palms of the hand, and under the fingernails or toenails. It is the least frequently diagnosed melanoma among the four histologic subtypes of cutaneous melanoma, accounting for less than 5% of all cases. ALM is frequently diagnosed at late stages and has higher incidences in non-white populations in relation to the other forms of cutaneous malignant melanoma. The most common sites of metastases in melanoma are the skin and subcutaneous tissue followed by lung, liver, brain, and bone. Bone metastases from malignant melanoma usually occur in patients who already have widespread metastases. We present this paper as a unique case study of ALM lesion in an 84-year-old African American male presenting originally in the base of right fifth toe plantar aspect then found multiple bone metastases without any other organ involved.

