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Updated: Jul 14, 2025

Focal Ca2+ Transient Detection in Smooth Muscle
Published on: June 29, 2009
Detection and estimation of multiple transient changes
Michael Baron1, Sergey V Malov2,3,4
1Department of Mathematics and Statistics, American University, Washington, DC, USA.
Abstract:
Change-point detection methods are proposed for the case of temporary failures, or transient changes, when an unexpected disorder is ultimately followed by a re-adjustment and return to the initial state. A base distribution of the 'in-control' state changes to an 'out-of-control' distribution for unknown periods of time. Likelihood based sequential and retrospective tools are proposed for the detection and estimation of each pair of change-points. The accuracy of the obtained change-point estimates is assessed. Proposed methods offer simultaneous control of the familywise false alarm and false re-adjustment rates at the pre-chosen levels.
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