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Clinical and Epidemiological Characteristics of Rhabdomyolysis: A Retrospective Study

Keke Sun1, Zhenhua Shi1,2, Yushanjiang Abudureheman1,3

  • 1Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, China.

International Journal of Clinical Practice
|October 9, 2023
PubMed
Abstract

Insights

Rhabdomyolysis (RM) can lead to acute kidney injury (AKI). Alcohol consumption, creatine kinase (CK), and creatinine are key risk factors for AKI in RM patients. Combining CK and creatinine offers improved prediction.

Area of Science:

  • Nephrology
  • Internal Medicine
  • Clinical Research

Background:

  • Rhabdomyolysis (RM) is a syndrome of muscle cell damage with symptoms like muscle pain, weakness, and dark urine.
  • Acute kidney injury (AKI) is a severe complication of RM, characterized by complex mechanisms and high mortality.
  • Early diagnosis and understanding RM pathogenesis are vital for improving patient prognosis.

Purpose of the Study:

  • To analyze the clinical and laboratory characteristics of Rhabdomyolysis (RM) patients.
  • To identify independent risk factors for acute kidney injury (AKI) in patients with RM.
  • To evaluate the predictive value of Creatine Kinase (CK) and creatinine for AKI in RM.

Main Methods:

  • Retrospective analysis of 71 Rhabdomyolysis (RM) patients' medical records from Tianjin Medical University General Hospital (October 2019 - October 2022).
  • Logistic regression analysis to identify risk factors for RM-complicated AKI.
  • Receiver operating characteristic (ROC) curve analysis to determine the predictive value of Creatine Kinase (CK) and creatinine.

Main Results:

  • The study included 71 RM patients, with a median age of 53.0 years; men were 2.5 times more affected than women.
  • Infection was the most common cause of RM.
  • History of alcohol consumption, elevated Creatine Kinase (CK), and creatinine levels were identified as independent risk factors for AKI in RM patients.
  • Logistic regression indicated that the combination of CK and creatinine had superior predictive value for AKI compared to either marker alone.

Conclusions:

  • This study provides insights into the clinical and laboratory features of RM and associated AKI in a specific patient population.
  • Alcohol consumption, CK, and creatinine are significant factors influencing AKI development in RM.
  • Combined assessment of CK and creatinine demonstrates enhanced predictive capability for AKI in RM patients, guiding clinical management.

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