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Updated: Jul 14, 2025

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Published on: October 19, 2021

Improved CAR-T cell activity associated with increased mitochondrial function primed by galactose.

Golda Gross^1,2, Suha Alkadieri^1,2, Amilia Meir¹

¹Cell Therapy Lab, Sheba Medical Center, Tel Hashomer, Israel.

Biorxiv : the Preprint Server for Biology

|October 9, 2023

Summary

Optimizing CAR-T cell metabolism by switching to galactose-based media enhances mitochondrial function and improves efficacy in B-cell malignancies. This metabolic shift boosts CAR-T cell effectiveness, offering a new strategy to improve patient outcomes.

Keywords:

CAR-T chimeric antigen receptor galactose immunotherapy metabolism mitochondria

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Area of Science:

Immunology
Cellular Metabolism
Oncology

Background:

Chimeric antigen receptor T-cell (CAR-T) therapy shows promise for B-cell malignancies but often faces long-term relapse.
Interventions to enhance CAR-T cell efficacy are under investigation, with a focus on cellular metabolism.
CD19-28z CAR-T cells are used in treating acute lymphoblastic leukemia.

Conclusions:

Mitochondrial metabolism is a critical determinant of CAR-T cell efficacy.
Switching the carbon source to galactose represents a translational strategy to enhance the metabolic fitness and anti-leukemia activity of clinical CAR-T cell products.
Metabolic optimization holds potential for improving long-term remission rates in patients with B-cell malignancies.