Related Experiment Video
Updated: Jul 14, 2025
04:02
Serial Two-Photon Tomography of the Whole Marmoset Brain for Neuroanatomical Analyses
Published on: January 17, 2025
478
A 4D transcriptomic map for the evolution of multiple sclerosis-like lesions in the marmoset brain
Jing-Ping Lin1, Alexis Brake1, Maxime Donadieu1
1Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
Biorxiv : the Preprint Server for Biology
|October 9, 2023
Summary
This study uses marmoset models to track multiple sclerosis (MS) lesion evolution, identifying key cellular roles in disease progression and repair. Findings offer new ways to assess treatment effectiveness for inflammatory demyelination.
Area of Science:
- Neuroimmunology
- Translational Neuroscience
- Molecular Pathology
Background:
- Postmortem studies of multiple sclerosis (MS) tissue lack dynamic lesion evolution insights.
- Developing therapies for inflammatory demyelination requires understanding lesion development and repair dynamics.
Conclusions:
- The common marmoset EAE model provides a platform to study MS lesion evolution.
- Specific cell types and molecular features are crucial for understanding and potentially targeting MS pathology.
- This research offers potential biomarkers for assessing therapeutic outcomes in MS treatment development.
