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Biomaterials combined with ADSCs for bone tissue engineering: current advances and applications.

Yiping Song1, Ning Wang1, Huixin Shi1

  • 1Department of Plastic Surgery, The First Hospital of China Medical University, Shenyang 110001, China.

Regenerative Biomaterials
|October 9, 2023
PubMed
Summary

Adipose-derived stem cells (ADSCs) show promise for bone tissue engineering. This review explores biomaterials that regulate ADSCs for enhanced bone defect repair, aiding clinical translation.

Keywords:
adipose-derived stem cellsangiogenesisbone tissue engineeringinflammationosteogenesis

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Area of Science:

  • Biomaterials Science
  • Stem Cell Biology
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Bone tissue engineering utilizes scaffolds, seed cells, and bioactive molecules for bone defect treatment.
  • Adipose-derived stem cells (ADSCs) are increasingly preferred over bone marrow mesenchymal stem cells due to accessibility and differentiation potential.
  • A lack of systematic guidance exists for selecting biomaterials to optimize ADSC behavior in bone regeneration.

Purpose of the Study:

  • To review the regulatory effects of various biomaterials on ADSC behavior.
  • To assess the impact of biomaterials on ADSC biocompatibility, inflammation, angiogenesis, and osteogenesis.
  • To evaluate the influence of bioactive molecules (BMs) on ADSC-mediated bone repair and clinical applications.

Main Methods:

  • Systematic review of literature on biomaterials and ADSCs in bone tissue engineering.
  • Analysis of ADSC responses (biocompatibility, inflammation, angiogenesis, osteogenesis) to different biomaterials.
  • Evaluation of the combined effects of biomaterials and bioactive molecules on bone repair.
  • Generalization of clinical case reports and experimental data.

Main Results:

  • Biomaterials significantly influence ADSC behavior, impacting key aspects of bone regeneration.
  • The combination of specific biomaterials and bioactive molecules can enhance ADSC-driven bone repair.
  • Clinical data suggests potential for ADSC-based bone tissue engineering strategies.

Conclusions:

  • Understanding biomaterial-ADSC interactions is crucial for effective bone defect treatment.
  • This review provides evidence for selecting optimal biomaterials and bioactive molecules for ADSC-based therapies.
  • Further research and clinical translation are supported by the summarized findings.