Related Experiment Video

Updated: Jul 14, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
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miR-708-3p promotes gastric cancer progression through downregulating ETNK1

Jincai Shang1, Qingdong Wang1, Jingren Wang1

  • 1Key Laboratory of Microecology-immune Regulatory Network and Related Diseases, School of Basic Medicine, Jiamusi University, Jiamusi, Heilongjiang, 154000, China.

Heliyon
|October 9, 2023
PubMed

Insights

MicroRNAs (miRNAs) like miR-708-3p are upregulated in gastric cancer, promoting tumor growth and poor survival. Targeting the miR-708-3p/ETNK1 pathway may offer new therapeutic strategies for gastric cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are key regulators in gastric cancer, influencing proliferation, metastasis, and chemo-resistance.
  • The specific role of miR-708-3p in gastric cancer progression and its therapeutic potential remain largely undefined.

Purpose of the Study:

  • To investigate the role and mechanism of miR-708-3p in gastric cancer progression.
  • To identify potential therapeutic targets and prognostic markers for gastric cancer.

Main Methods:

  • Analysis of miR-708-3p expression in gastric cancer samples.
  • In vitro functional assays (proliferation, migration, apoptosis, cell cycle analysis).
  • In vivo experiments in nude mice and mechanistic studies involving ETNK1 regulation.

Main Results:

  • miR-708-3p is upregulated in gastric cancer and associated with poor patient survival.
  • Overexpression of miR-708-3p promotes gastric cancer cell proliferation, migration, and G0/G1 to G2/M phase transition, while inhibiting apoptosis.
  • miR-708-3p targets and downregulates ethanolamine kinase 1 (ETNK1) expression, promoting tumor growth in vivo.

Conclusions:

  • A novel miR-708-3p/ETNK1 pathway is identified as a crucial driver of gastric cancer progression.
  • miR-708-3p and ETNK1 represent potential therapeutic targets and prognostic biomarkers for gastric cancer.
Keywords:
ETNK1Gastric cancermiR-708–3p

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