Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

2.8K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
2.8K
Hemoglobin01:24

Hemoglobin

3.7K
Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
3.7K
Respiration and Gaseous Exchange01:20

Respiration and Gaseous Exchange

1.5K
The intricate interplay between the cardiovascular and respiratory systems is crucial for efficiently transporting respiratory gases throughout the body. Let us explore the cardiovascular system's multifaceted functions, emphasizing its pivotal role in gas exchange.
Respiration involves the exchange of gases, especially oxygen (O2) and carbon dioxide (CO2), between the alveoli and body cells, a process facilitated by blood circulation. As a result, the cardiovascular system, which involves...
1.5K
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

3.3K
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
3.3K
Protein and Protein Structure02:15

Protein and Protein Structure

79.7K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
79.7K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

7.9K
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-Dimensional Assessment of Low-Carbon Engineering Cement-Based Composites Based on Rheological, Mechanical and Sustainability Factors.

Materials (Basel, Switzerland)·2026
Same author

Rust Distribution of Non-Uniform Steel Corrosion Induced by Impressed Current Method.

Materials (Basel, Switzerland)·2022
Same author

Effects of Reinforcement Corrosion and Sustained Load on Mechanical Behavior of Reinforced Concrete Columns.

Materials (Basel, Switzerland)·2022
Same author

Macrocell Corrosion of Steel in Concrete under Carbonation, Internal Chloride Admixing and Accelerated Chloride Penetration Conditions.

Materials (Basel, Switzerland)·2021
Same author

Assessment of Electrical Resistivity and Oxygen Diffusion Coefficient of Cementitious Materials from Microstructure Features.

Materials (Basel, Switzerland)·2021
Same author

Theoretical and Experimental Study on the Effective Piezoelectric Properties of 1-3 Type Cement-Based Piezoelectric Composites.

Materials (Basel, Switzerland)·2018

Related Experiment Video

Updated: Jul 14, 2025

Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats
09:47

Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats

Published on: June 14, 2024

611

Structural optimization and prospect of constructing hemoglobin oxygen carriers based on hemoglobin.

Yuexiang Ma1, Qi Zhang1, Zheng Dai1

  • 1Department of Emergency, Xijing Hospital, Air Force Medical University, Xi'an, 710032, Shaanxi Province, China.

Heliyon
|October 9, 2023
PubMed
Summary

Hemoglobin-based oxygen carriers (HBOCs) offer significant advantages for organ preservation, addressing limitations of current methods. Research focuses on developing safe, effective HBOCs to improve organ storage and transplantation outcomes.

Keywords:
Chemical modificationHemoglobin-based oxygen carriersOrgans storageRed blood cells

More Related Videos

Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy
09:12

Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy

Published on: June 14, 2024

940
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

9.9K

Related Experiment Videos

Last Updated: Jul 14, 2025

Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats
09:47

Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats

Published on: June 14, 2024

611
Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy
09:12

Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy

Published on: June 14, 2024

940
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

9.9K

Area of Science:

  • Biomedical Engineering
  • Transplantation Science
  • Materials Science

Background:

  • Global organ shortage and donor-recipient mismatch necessitate improved organ preservation techniques.
  • Current organ preservation methods face challenges including short shelf-life and risk of complications.
  • Hemoglobin-based oxygen carriers (HBOCs) exhibit beneficial properties like anti-apoptotic and antioxidant effects.

Purpose of the Study:

  • To review advancements in understanding HBOC mechanisms for organ preservation.
  • To highlight the potential of HBOCs in overcoming limitations of current organ storage solutions.
  • To emphasize the need for designing optimal HBOCs for diverse organ transplantation applications.

Main Methods:

  • Review of existing literature on HBOCs and organ preservation.
  • Analysis of HBOC properties relevant to organ storage (e.g., oxygen-carrying capacity, safety).
  • Discussion of recent progress in understanding HBOC mechanisms.

Main Results:

  • HBOCs demonstrate significant advantages, including anti-apoptotic, anti-inflammatory, antioxidant, and anti-proliferative effects.
  • These properties are crucial for mitigating organ damage during preservation.
  • Advancements in understanding HBOC mechanisms are paving the way for improved applications.

Conclusions:

  • HBOCs present a promising strategy for enhancing organ preservation.
  • Further research and development are needed to create widely applicable and organ-specific HBOCs.
  • Optimized HBOCs can potentially improve organ viability, extend shelf-life, and reduce transplantation risks.